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Proceedings Paper

Laser-tissue interaction
Author(s): Ashley J. Welch
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Paper Abstract

The response of tissue to laser radiation spans the gauntlet from biostimulation at irradiance levels of mW to the violent disruptions of tissue with short pulses that have MW peak irradiances. The end result of laser interaction with tissue is governed by energy Deposition that depends upon laser parameters and tissue properties. In concept, PDT requires a laser wavelength that matches an absorption peak of the photosensitizer and a penetration depth to reach all of the targeted tissue. Dosimetry will depend upon the needed fluence rate 4(z) of the light at the targeted depth. Given the optical properties of the tissue, various methods of solving the transport equation can be used to calculate fluence rate [W1m2] as a function of depth. Since most wavelengths of interest for PDT are in the red and near IR, scattering dominates absorption; and the fluence rate just below the surface of tissue can be much larger than the irradiance, EO [W/m2].

Paper Details

Date Published: 5 December 1996
PDF: 1 pages
Proc. SPIE 2923, Laser-Tissue Interaction and Tissue Optics II, (5 December 1996); doi: 10.1117/12.260745
Show Author Affiliations
Ashley J. Welch, Univ. of Texas/Austin (United States)

Published in SPIE Proceedings Vol. 2923:
Laser-Tissue Interaction and Tissue Optics II
Hansjoerg Albrecht; Guy P. Delacretaz; Thomas H. Meier; Rudolf W. Steiner; Lars Othar Svaasand, Editor(s)

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