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Proceedings Paper

Photodynamic therapy (PDT) in advanced inoperable bronchial carcinoma
Author(s): Keyvan Moghissi; Kate Dixon; Mark R. Stringer; Stanley B. Brown
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Paper Abstract

Objective: To assess the efficacy of PDT to: Palliate symptoms, control disease and extend survival in patients with advanced inoperable cancer. Subject and Method: 55 Males and 23 females aged between 45-81 years (mean 66 years) with inoperable and advanced lung cancer with > 5O. obstructive lesions of the main, lobar or segmental bronchi. Patients had pre-treatment routine clinical radiological, functional and endoscopic assessment with proven histological diagnosis. Protocol of PDT was; Intravenous injection of 2 mg/Kg bodyweight Polyhaematoporphyrin (equivalent to Photofrin) or Photofrin followed 24-72 hours later by illumination of tumour using 630 nm light (Oxford Laser) delivered via an optical fibre with end diffuser. Treatments were carried out under general anaesthesia as a day case procedure. Patients were rebronchoscoped for debridement/retreatment 4-7 days later. Results: There was no treatment related mortality. Two patients developed mild photosensitivity reaction. All patients showed symptomatic improvement with good initial functional and radiological amelioration. Every patient responded to treatment. Seven patients had complete response and negative histology for 3-12 months. After the first treatment average Forced Vital Capacity (FVC) and Forced Expiratory Volume in one second (FEV1) improvement was 0.5 litres and 0.4 litres respectively. Twenty five percent of patients (nr 19) survived more than 2 years, 10'. (nr=8) between 1-2 years and the remaining 51 patients less than a year. Conclusion: PDT should be considered as a therapeutic modality for all stages of lung cancer and is an excellent treatment modality for palliation in advanced bronchial malignancies.

Paper Details

Date Published: 3 December 1996
PDF: 7 pages
Proc. SPIE 2922, Laser Applications in Medicine and Dentistry, (3 December 1996); doi: 10.1117/12.260700
Show Author Affiliations
Keyvan Moghissi, Goole & District Hospital, Univ. of Hull, and Univ. of Leeds (United Kingdom)
Kate Dixon, Goole & District Hospital, Univ. of Hull, and Univ. of Leeds (United Kingdom)
Mark R. Stringer, Goole & District Hospital, Univ. of Hull, and Univ. of Leeds (United Kingdom)
Stanley B. Brown, Goole & District Hospital, Univ. of Hull, and Univ. of Leeds (United Kingdom)

Published in SPIE Proceedings Vol. 2922:
Laser Applications in Medicine and Dentistry
Gregory B. Altshuler; Fausto Chiesa; Herbert J. Geschwind M.D.; Raimund Hibst; Neville Krasner M.D.; Frederic Laffitte; Giulio Maira; Reinhard Neumann; Roberto Pini; Hans-Dieter Reidenbach; Andre Roggan; Montserrat Serra I Mila, Editor(s)

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