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Proceedings Paper

Characterization of human skin using optical coherence tomography
Author(s): Valentin M. Gelikonov; Alexander M. Sergeev; Grigory V. Gelikonov; Felix I. Feldchtein; Natalia D. Gladkova; John Ioannovich; K. Frangia; T. Pirza; V. Zhegalov; D. Aleinik; I. Vazina; Ludmila Snopova; Ioannis Antoniou
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Paper Abstract

We report the results of clinical test of a compact, fast- scanning OCT device, elaborated in the Institute of Applied Physics Russian Academy of Sciences. The device is based on a polarization-preserving optical fiber. Michelson interferometer with an integrated unit for fast electro- optic scanning in the depth of the investigated tissue. An essential advantage of the polarization-preserving fiber interferometer scheme consists in employing a flexible fiber cable in the sample arm. This is principal for clinical applications of the OCT, first of all in dermatology and endoscopy studying of internal organs. The compact OCT device includes a 1.5 mW superluminescent source of radiation at the wavelength of 0.83 mcm with the 30 nm spectral width. It enables to produce 200 by 200 images for approximately 1 s acquisition time. Clinical tests of the device have been focused on monitoring of pathological and postoperative states and burns of human skin in vivo and in vitro and determining optical characteristics (refraction index, scattering coefficients) of human tissues. Parallel histological study of postoperative specimens has been carried out. Recently developed OCT device for simultaneous dual-wavelength imaging will allow to distinguish better absorbing and scattering structures and differentiate melanocytic skin lesions including tumors.

Paper Details

Date Published: 11 December 1996
PDF: 8 pages
Proc. SPIE 2927, Optical and Imaging Techniques for Biomonitoring II, (11 December 1996); doi: 10.1117/12.260644
Show Author Affiliations
Valentin M. Gelikonov, Institute of Applied Physics (Russia)
Alexander M. Sergeev, Institute of Applied Physics (Russia)
Grigory V. Gelikonov, Institute of Applied Physics (Russia)
Felix I. Feldchtein, Institute of Applied Physics (Russia)
Natalia D. Gladkova, Institute of Applied Physics (Russia)
John Ioannovich, General State Hospital (Greece)
K. Frangia, General State Hospital (Greece)
T. Pirza, General State Hospital (Greece)
V. Zhegalov, Nizhny Novgorod Institute for Orthopedy and Traumatology (Russia)
D. Aleinik, Nizhny Novgorod Institute for Orthopedy and Traumatology (Russia)
I. Vazina, Nizhny Novgorod Institute for Orthopedy and Traumatology (Russia)
Ludmila Snopova, Nizhny Novgorod Medical Academy (Russia)
Ioannis Antoniou, International Solvay Institute for Physics and Chemistry (Belgium)

Published in SPIE Proceedings Vol. 2927:
Optical and Imaging Techniques for Biomonitoring II
Hans-Jochen Foth; Renato Marchesini; Halina Podbielska M.D., Editor(s)

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