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Proceedings Paper

Irradiation with HeNe laser can influence the cytotoxic response of HeLa cells to ionizing radiation
Author(s): Tiina I. Karu; Ludmila V. Pyatibrat; G. Kalendo
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Paper Abstract

A monolayer of HeLa cells in plateau-phase of growth was exposed to He-Ne laser radiation either 5 min, 60 min or 180 min before (gamma) -irradiation. It has been shown that in the case of a 5-min interval between the two types of irradiations the survival curve was practically identical to the survival curve of the cells after (gamma) -irradiation only. In the case of He-Ne laser exposure 60 min before (gamma) -irradiation with doses of over 5 Gy, a fraction of more resistant cells was revealed: their D0 was twice as high as the D0 of the min population. A preexposure of cells to He-Ne laser 60 or 180 min before (gamma) - irradiation also changed the shape of the growth curves as compared to (gamma) -irradiated cells. It is proposed that the preexposure of cells to He-Ne laser radiation activates, in a subpopulation of cells, processes which speed up the repair of (gamma) -radiation damage. The possibility that the described phenomenon is an adaptive response of cells is discussed.

Paper Details

Date Published: 25 November 1996
PDF: 9 pages
Proc. SPIE 2929, Effects of Low-Power Light on Biological Systems II, (25 November 1996); doi: 10.1117/12.260004
Show Author Affiliations
Tiina I. Karu, Laser Technology Research Ctr. (Russia)
Ludmila V. Pyatibrat, Laser Technology Research Ctr. (Russia)
G. Kalendo, Russian Cancer Research Ctr. (Russia)

Published in SPIE Proceedings Vol. 2929:
Effects of Low-Power Light on Biological Systems II
Giulio Jori; Tiina I. Karu, Editor(s)

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