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Proceedings Paper

Optical fiber device for simultaneous manometry, pH-metry and bilimetry in esophagus (OPTIMO) (Conference Presentation)

Paper Abstract

The target of the present research is the design, implementation and characterization of a portable device based on an all-optical technology capable to perform simultaneously esophageal manometry, pH-metry and bilimetry by means of a single or combined catheter (OPTIMO project). It will provide physicians a compact and reliable tool to perform exhaustive diagnosis in gastroesophageal reflux pathologies. It would be definitely an innovative product in the gastroesophageal diagnostic scenario with high potential for worldwide market penetration and application developments. In particular, pressure measurement along the esophagus is performed with an array of optical fiber gratings, which ensures the monitoring along a length of about 30 cm with high spatial resolution. The sensors for the measurement of pH and bile are based on the change in absorption caused by the parameter under investigation. In the case of pH, an acid-base indicator that changes its absorption as a function of pH is immobilized on controlled pore glasses suitable coupled to plastic optical fibers. As for bile detection, the measurement is based on the direct absorption of bilirubin, the main biliary pigment, and a bundle of plastic optical fibers carries the signal. With a planned clinical assessment of the realized device, the achievement of this main objective implies the accomplishment of the following sub-tasks: i) development of optical fiber sensor for the measurement of pH; ii) development of the optical fiber sensor for bile detection; iii) development of the optical fiber manometer; iv) integration of the optical fiber sensors within a single catheter; v) realization of the portable interrogation unit for all the three parameters; vi) clinical assessment of the final device on both volunteers and patients.

Paper Details

Date Published: 1 April 2020
Proc. SPIE 11361, Biophotonics in Point-of-Care, 113610U (1 April 2020); doi: 10.1117/12.2555710
Show Author Affiliations
Francesco Chiavaioli, Istituto di Fisica Applicata "Nello Carrara", Consiglio Nazionale delle Ricerche (Italy)
Giovanni Bartolozzi, Istituto di Fisica Applicata "Nello Carrara", Consiglio Nazionale delle Ricerche (Italy)
Manfred Rothhardt, Leibniz-Institut für Photonische Technologien e.V. (Germany)
Kerstin Schroeder, Leibniz-Institut für Photonische Technologien e.V. (Germany)
Tobias Habisreuther, Leibniz-Institut für Photonische Technologien e.V. (Germany)
Martin Hahn, OSCOMED GmbH (Germany)
Olivier M. Rados, OSCOMED GmbH (Germany)
Florian Mönkediek, OSCOMED GmbH (Germany)
Steffen Görlich, JETI Technische Instrumente GmbH (Germany)
Johannes Gäbler, JETI Technische Instrumente GmbH (Germany)
Antonio Taddei, Azienda Ospedaliera Univ. Careggi (Italy)
Maria Novella Ringressi, Azienda Ospedaliera Univ. Careggi (Italy)
Ilenia Bartolini, Azienda Ospedaliera Univ. Careggi (Italy)
Piero Cecchi, Cecchi s.r.l. (Italy)
Francesco Baldini, Istituto di Fisica Applicata "Nello Carrara", Consiglio Nazionale delle Ricerche (Italy)

Published in SPIE Proceedings Vol. 11361:
Biophotonics in Point-of-Care
Michael T. Canva; Ambra Giannetti; Hatice Altug; Julien Moreau, Editor(s)

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