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Proceedings Paper

Using in utero optical coherence tomography to evaluate changes in murine fetal brain vasculature due to prenatal exposure to teratogens (Conference Presentation)

Paper Abstract

One of the most common reasons of congenital birth defects is prenatal substance abuse. The severity of the defect depends on the amount of substance abused and the period of gestation during which substance is abused. Although prenatal substance abuse is common during the first trimester, some women continue the abuse well into their second trimester, which is considered the peak period for fetal neurogenesis and angiogenesis. Thus, evaluating the changes in fetal brain vasculature caused by maternal exposure to different teratogens at the second trimester equivalent period is crucial. In this study we use correlation mapping optical coherence angiography (cm-OCA), a functional extension of optical coherence tomography, to image changes in murine fetal brain vasculature caused due to prenatal exposure to ethanol, cannabinoids, or nicotine. Results showed significant vasoconstriction in all three cases.

Paper Details

Date Published: 2 April 2020
Proc. SPIE 11363, Tissue Optics and Photonics, 1136303 (2 April 2020); doi: 10.1117/12.2555621
Show Author Affiliations
Raksha Raghunathan, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Amur Kouka, Univ. of Houston (United States)
Yogeshwari Sanjayrao Ambekar, Univ. of Houston (United States)
Connie Yan, Univ. of Houston (United States)
Noemi Bustamante, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Rajesh C. Miranda, Texas A&M Health Science Ctr. (United States)
Kirill V. Larin, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 11363:
Tissue Optics and Photonics
Valery V. Tuchin; Walter C. P. M. Blondel; Zeev Zalevsky, Editor(s)

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