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Proceedings Paper

Stain-free optical biomarkers for bladder cancer tissues based on interferometric phase microscopy (Conference Presentation)

Paper Abstract

We developed stain-free optical biomarkers for high-grade T1 bladder cancer tissues based on interferometric phase microscopy (IPM). IPM records a topographic map that represents, for each spatial point, the integral of the refractive-index values along the tissue sample thickness, thus accounting for both the tissue internal morphology and contents. Following the extraction of various parameters from this IPM-based topographic maps of healthy and bladder cancer tissues, we employed a machine learning multivariant analysis for stain-free grading of the bladder cancer invasiveness. Our tools are expected to be used for rapid and inexpensive diagnosis of bladder cancer tissues.

Paper Details

Date Published: 2 April 2020
Proc. SPIE 11363, Tissue Optics and Photonics, 113630H (2 April 2020); doi: 10.1117/12.2555315
Show Author Affiliations
Natan T. Shaked, Tel Aviv Univ. (Israel)
Miki Haifler, Tel Aviv Univ. (Israel)
Ofer Goldstein, Tel Aviv Univ. (Israel)
Almog Yogev, Tel Aviv Univ. (Israel)

Published in SPIE Proceedings Vol. 11363:
Tissue Optics and Photonics
Valery V. Tuchin; Walter C. P. M. Blondel; Zeev Zalevsky, Editor(s)

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