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Proceedings Paper

Optical fine needle biopsy in hepatocellular carcinoma mouse model
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Paper Abstract

The paper describes the results of experimental studies using custom developed optical biopsy system for diagnostics in vivo during the procedure of fine needle aspiration biopsy. Experimental studies were conducted in laboratory mice with inoculated hepatocellular carcinoma. The measurements were carried out using fluorescence spectroscopy and diffuse reflectance spectroscopy methods to reveal metabolic and morphological changes in tissues. The results show that the developed approach is sensitive for cancer detection. Quantified differences in the maximum of fluorescence spectra and diffuse reflectance spectra between tumor and normal tissues were demonstrated and approved with morphological analysis.

Paper Details

Date Published: 2 April 2020
PDF: 6 pages
Proc. SPIE 11363, Tissue Optics and Photonics, 113630V (2 April 2020); doi: 10.1117/12.2555154
Show Author Affiliations
Elena Potapova, Orel State Univ. (Russian Federation)
Ksenia Kandurova, Orel State Univ. (Russian Federation)
Valery Shupletsov, Orel State Univ. (Russian Federation)
Evgeniya Seryogina, Orel State Univ. (Russian Federation)
Viktor Dremin, Orel State Univ. (Russian Federation)
Univ. of Oulu (Finland)
Evgeny Zherebtsov, Orel State Univ. (Russian Federation)
Univ. of Oulu (Finland)
Alexander Alekseyev, Orel State Univ. (Russian Federation)
Andrian Mamoshin, Orel State Univ. (Russian Federation)
Orel Regional Clinical Hospital (Russian Federation)
Yuri Ivanov, Federal Scientific and Clinical Ctr. for Specialized Medical Service and Medical Technologies (Russian Federation)
Central Research Institute of Tuberculosis (Russian Federation)
Dmitry Panchenkov, A.I. Yevdokimov Moscow State Univ. of Medicine and Dentistry (Russian Federation)
Andrey Dunaev, Orel State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11363:
Tissue Optics and Photonics
Valery V. Tuchin; Walter C. P. M. Blondel; Zeev Zalevsky, Editor(s)

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