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Proceedings Paper

Automated surgical margin assessment in breast conserving surgery using SFDI with ensembles of self-confident deep convolutional networks
Author(s): Arturo Pardo; José A. Gutiérrez-Gutiérrez; Samuel S. Streeter; Benjamin W. Maloney; José M. López-Higuera; Brian W. Pogue; Olga M. Conde
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Paper Abstract

With an adequate tissue dataset, supervised classification of tissue optical properties can be achieved in SFDI images of breast cancer lumpectomies with deep convolutional networks. Nevertheless, the use of a black-box classifier in current ex vivo setups provides output diagnostic images that are inevitably bound to show misclassified areas due to inter- and intra-patient variability that could potentially be misinterpreted in a real clinical setting. This work proposes the use of a novel architecture, the self-introspective classifier, where part of the model is dedicated to estimating its own expected classification error. The model can be used to generate metrics of self-confidence for a given classification problem, which can then be employed to show how much the network is familiar with the new incoming data. A heterogenous ensemble of four deep convolutional models with self-confidence, each sensitive to a different spatial scale of features, is tested on a cohort of 70 specimens, achieving a global leave-one-out cross-validation accuracy of up to 81%, while being able to explain where in the output classification image the system is most confident.

Paper Details

Date Published: 1 April 2020
PDF: 13 pages
Proc. SPIE 11362, Clinical Biophotonics, 113620I (1 April 2020); doi: 10.1117/12.2554965
Show Author Affiliations
Arturo Pardo, Univ. de Cantabria (Spain)
Instituto de Investigación Valdecilla (IDIVAL) (Spain)
José A. Gutiérrez-Gutiérrez, Univ. de Cantabria (Spain)
Instituto de Investigación Valdecilla (IDIVAL) (Spain)
Samuel S. Streeter, Thayer School of Engineering at Dartmouth (United States)
Benjamin W. Maloney, Thayer School of Engineering at Dartmouth (United States)
José M. López-Higuera, Univ. de Cantabria (Spain)
Instituto de Investigación Valdecilla (IDIVAL) (Spain)
Ctr. de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (Spain)
Brian W. Pogue, Thayer School of Engineering at Dartmouth (United States)
Olga M. Conde, Univ. de Cantabria (Spain)
Instituto de Investigación Valdecilla (IDIVAL) (Spain)
Ctr. de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (Spain)


Published in SPIE Proceedings Vol. 11362:
Clinical Biophotonics
Daniel S. Elson; Sylvain Gioux; Brian W. Pogue, Editor(s)

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