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Measurement of optical properties of normal and pathological human liver tissue from deep-UV to NIR
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Paper Abstract

The interest of using light in clinical practice is increasing strongly and many applications work at various wavelengths from the ultraviolet to the infrared. Due to this great range of applications, the determination of the optical properties of biological tissues in a wide spectral range becomes of interest. The liver is an important organ, since it has a major role in the human body and various pathologies are known to develop within it. For these reasons, this study concerns the estimation of the optical properties of human normal and pathological (metastatic carcinoma) liver tissues between 200 and 1000 nm. The obtained optical properties present the expected wavelength dependencies for both tissues – the refractive index, the absorption and the scattering coefficients decrease with the wavelength and the anisotropy and light penetration depth increase with the wavelength. Although similar behavior was observed for the various properties between the normal and pathological tissues, evidence of smaller blood content in the pathological tissues was found. A possible explanation is that the cancer cells destroy liver’s vasculature and internal architecture, providing though a reduction in the blood content. For low wavelengths, it was observed a matching between the scattering and the reduced scattering coefficients, which implies a nearly zero anisotropy in that range. The scattering coefficient decreases from nearly 140 cm-1 (at 200 nm) to 80 cm-1 (at 1000 nm) for the normal liver and from nearly 140 cm-1 (at 200 nm) to 95 cm-1 (at 1000 nm) for the pathological tissue.

Paper Details

Date Published: 2 April 2020
PDF: 14 pages
Proc. SPIE 11363, Tissue Optics and Photonics, 113630G (2 April 2020); doi: 10.1117/12.2554877
Show Author Affiliations
I. Carneiro, Portuguese Oncology Institute of Porto (Portugal)
S. Carvalho, Portuguese Oncology Institute of Porto (Portugal)
R. Henrique, Portuguese Oncology Institute of Porto (Portugal)
Univ. of Porto (Portugal)
L. Oliveira, ISEP (Portugal)
Polytechnic of Porto (Portugal)
V. V. Tuchin, Saratov State Univ. (Russian Federation)
Precision Mechanics and Control Institute (Russian Federation)
Tomsk State Univ. (Russian Federation)

Published in SPIE Proceedings Vol. 11363:
Tissue Optics and Photonics
Valery V. Tuchin; Walter C. P. M. Blondel; Zeev Zalevsky, Editor(s)

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