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Proceedings Paper

Controlling the embryonic heart beat through optogenetics (Conference Presentation)
Author(s): Andrew L. Lopez III; Irina V. Larina

Paper Abstract

Biomechanical signaling is required during cardiac development. Perturbation of heart biomechanics results in a malformed heart, the primary phenotype found in congenital heart disease. Cardiac progenitor cells are responsible for acquiring all cardiac cell fates, expanding, and organizing into a functional heart. How biomechanical signals govern cardiac progenitor cell behavior to achieve cardiac morphogenesis is unknown. In this work, we will implement optogenetic cardiac pacing as a means to control cardiac biomechanics and determine how altered mechanics affects cardiac progenitor cells.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390V (9 March 2020); doi: 10.1117/12.2554349
Show Author Affiliations
Andrew L. Lopez III, Baylor College of Medicine (United States)
Irina V. Larina, Baylor College of Medicine (United States)


Published in SPIE Proceedings Vol. 11239:
Dynamics and Fluctuations in Biomedical Photonics XVII
Valery V. Tuchin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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