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Proceedings Paper

Optical coherence angiography reveals changes in murine fetal brain vasculature due to maternal exposure to nicotine
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Paper Abstract

In the United States, 20% of pregnant women are estimated to smoke, thus affecting 800,000 babies annually. Maternal nicotine exposure is known to have several detrimental effects on the developing fetus including intrauterine growth restriction, perinatal mortality and morbidity, placental abruption, and other childhood disorders. In humans, studies evaluating the association between maternal cigarette smoking during pregnancy and behavioral development in offsprings have shown negative influences of nicotine on brain development. Although several studies have documented lower birth weights, morphological and behavioral changes, not much has been done evaluating the acute changes in brain vasculature after prenatal exposure to nicotine. This work uses correlation mapping optical coherence angiography (cm-OCA), a functional extension of optical coherence tomography, to evaluate changes in murine fetal brain vasculature, in utero, minutes after maternal nicotine exposure. A rapid and significant decrease in vasculature was observed compared to the sham group.

Paper Details

Date Published: 21 February 2020
PDF: 5 pages
Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390D (21 February 2020);
Show Author Affiliations
Raksha Raghunathan, Univ. of Houston (United States)
Chih-Hao Liu, Univ. of Houston (United States)
Amur Kouka, Univ. of Houston (United States)
Yogeshwari Ambekar, Univ. of Houston (United States)
Connie Yan, Univ. of Houston (United States)
Noemi Bustamante, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Rajesh C. Miranda, Texas A&M Health Science Ctr. (United States)
Kirill V. Larin, Univ. of Houston (United States)

Published in SPIE Proceedings Vol. 11239:
Dynamics and Fluctuations in Biomedical Photonics XVII
Valery V. Tuchin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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