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Proceedings Paper

Quantitative 4D OCT imaging of tubular mouse embryonic heart reveals its localized pumping mechanism
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Paper Abstract

We present an imaging-based quantitative approach for studying the localized pumping mechanism of the early tubular heart in live mouse embryos. The method relies on 4D (3D+time) imaging of cardiodynamics and hemodynamics of the embryonic heart using structural and Doppler optical coherence tomography (OCT). Our results from the mouse embryo at embryonic day 9.0 (E9.0) show an interesting relationship between the endocardial luminal areas and the localized volumetric blood flows, suggesting that a localized pressure gradient induced by the heart wall movement causes the variation of blood flows, including both the velocity magnitude and flow direction. Data provide new insights into the pumping mechanism of the mammalian tubular heart at the early developmental stage.

Paper Details

Date Published: 24 February 2020
PDF: 6 pages
Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390A (24 February 2020); doi: 10.1117/12.2553962
Show Author Affiliations
Shang Wang, Stevens Institute of Technology (United States)
Riana Syed, Baylor College of Medicine (United States)
Irina V. Larina, Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 11239:
Dynamics and Fluctuations in Biomedical Photonics XVII
Valery V. Tuchin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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