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Proceedings Paper

Use of 3-D photographic images to document changes in tumor volume following photodynamic therapy in patients with basal cell carcinoma of the skin
Author(s): Taylor Bullock; Jeffrey Negrey; Urvashi Kaw; Christine Warren; Edward V. Maytin
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Paper Abstract

Basal cell carcinoma (BCC) is a common skin cancer caused by chronic UV exposure. Photodynamic therapy (PDT), a non-surgical, non-scarring modality, can clear superficial BCC lesions but thick (nodular) lesions are more refractory. To improve overall PDT efficacy for BCC, we are conducting a clinical trial to ascertain whether neoadjuvant treatment with Vitamin D prior to ALA-PDT (5-aminolevulinic acid and blue light) can improve the rate of tumor clearance. Study patients undergo three PDT treatments, with sessions spaced two months apart. Prior to each PDT session, patients take a Vitamin D pill or a placebo pill for up to 14 days, in a randomized double-blind fashion. To quantify tumor shrinkage after each PDT treatment, we are employing high-precision 3D photography using a LifeViz Micro camera (Quantificare, Inc). With this approach, individual tumors are rendered in 3D coordinate space and important parameters such as tumor height and volume, which could not otherwise be obtained using standard photography, are measured. Amongst 45 BCC lesions evaluated, 17 (37.8%) disappeared after the first PDT treatment, 12 (26.7%) after the second, and 7 (15.6%) after the third, for a final clinical clearance rate of 80%. For treatment-responsive lesions, decreases in absolute volume after the first, second, and third treatment were 81.4%, 66.2%, and 80.9%, respectively. Corresponding decreases in lesion surface area were 78.8%, 70.2%, and 77.6%. The similar incremental changes in lesion size after each treatment reassures us that this technique can be used to successfully determine BCC clearance rates ± Vitamin D.

Paper Details

Date Published: 24 February 2020
PDF: 10 pages
Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200L (24 February 2020); doi: 10.1117/12.2553360
Show Author Affiliations
Taylor Bullock, Dermatology and Plastic Surgery Institute (United States)
Lerner Research Institute - Cleveland Clinic (United States)
Jeffrey Negrey, Cleveland Clinic (United States)
Urvashi Kaw, Dermatology and Plastic Surgery Institute, Cleveland Clinic (United States)
Christine Warren, Dermatology and Plastic Surgery Institute, Cleveland Clinic (United States)
Lerner Research Institute - Cleveland Clinic (United States)
Edward V. Maytin, Dermatology and Plastic Surgery Institute (United States)
Cleveland Clinic (United States)
Cleveland Clinic Lerner College of Medicine (United States)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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