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Use of peptide capture agents in porous silicon biosensors
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Paper Abstract

We report the use of a peptide-based capture agent as an alternative to antibodies and nucleic acid-based bioreceptors for porous silicon biosensors. Click chemistry is employed to attach azide-functionalized streptavidin-binding peptides to alkyne-modified porous silicon films. The attachment of the streptavidin-binding peptide and subsequent detection of streptavidin molecules are verified using optical reflectance and Fourier transform infrared spectroscopy measurements.

Paper Details

Date Published: 21 February 2020
PDF: 7 pages
Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 112580L (21 February 2020); doi: 10.1117/12.2552932
Show Author Affiliations
Tengfei Cao, Vanderbilt Univ. (United States)
Rabeb Layouni, Vanderbilt Univ. (United States)
Matthew B. Coppock, U.S. Army Combat Capabilities Development Command (United States)
Paul E. Laibinis, Vanderbilt Univ. (United States)
Sharon M. Weiss, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 11258:
Frontiers in Biological Detection: From Nanosensors to Systems XII
Amos Danielli; Benjamin L. Miller; Sharon M. Weiss, Editor(s)

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