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Proceedings Paper

Transcleral high resolution optical phase imaging of the retina (Conference Presentation)
Author(s): Christophe Moser; Timothé Laforest; Laura Kowalczuk; Francine Behar-Cohen; Mathieu Künzi

Paper Abstract

The retina is composed of several transparent layers of neuronal and glial cells active during the vision process. Several studies showed that their structure and density is impacted by numerous eye diseases, such as macular degeneration, glaucoma and retinis pigmentosa. Quantifying such small morphological changes in retinal cells at different depths is of considerable interest to understand the root cause of the diseases as well as to follow the efficacy of new therapeutic approaches. A widespread method to observe the retina ex-vivo at the cellular level is fluorescent confocal microscopy. However, a different imaging technique than fluorescence is required for in-vivo imaging in humans. We have shown that by using a combination of oblique illumination of the retina through the sclera, a phase image of the different layers can be generated and quantified.

Paper Details

Date Published: 11 March 2020
Proc. SPIE 11249, Quantitative Phase Imaging VI, 112490Z (11 March 2020);
Show Author Affiliations
Christophe Moser, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Timothé Laforest, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Laura Kowalczuk, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Francine Behar-Cohen, Univ. Paris Descartes (France)
Mathieu Künzi, Earlysight SA (Switzerland)

Published in SPIE Proceedings Vol. 11249:
Quantitative Phase Imaging VI
Yang Liu; Gabriel Popescu; YongKeun Park, Editor(s)

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