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Proceedings Paper

Tribulations in medicine: designing and implementing a trial of PDT plus vitamin D3 for high-grade anal dysplasia and microinvasive anal cancer (Conference Presentation)

Paper Abstract

We have initiated a clinical trial to test the hypothesis that we hypothesize that PDT with the photosensitizing pro-drug ALA and vitamin D3 can be applied to treat anal (pre)malignancy with acceptable toxicity and light dose delivery (NCT02698293) . Here, we report on the design of the trial, a custom apparatus to deliver light while measuring PpIX fluorescence and tissue optical properties, validation of apparatus and initial toxicity in the first treated patients.

Paper Details

Date Published: 10 March 2020
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Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200H (10 March 2020);
Show Author Affiliations
Keith A. Cengel, Penn Medicine (United States)
Timothy C. Zhu, Penn Medicine (United States)
Sally McNulty, Penn Medicine (United States)
Edgar Ben-Josef, Penn Medicine (United States)
Theresa M. Busch, Penn Medicine (United States)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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