Share Email Print

Proceedings Paper

Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems
Author(s): David Abookasis; David Shemesh; Naor Bokobza; Hadas Bloygrund; Yarden Franjy-Tal; Konstantin Rozenberg; Tovit Rosenzweig
Format Member Price Non-Member Price
PDF $17.00 $21.00

Paper Abstract

In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.

Paper Details

Date Published: 1 April 2020
PDF: 6 pages
Proc. SPIE 11360, Neurophotonics, 113600F (1 April 2020); doi: 10.1117/12.2551867
Show Author Affiliations
David Abookasis, Ariel Univ. (Israel)
David Shemesh, Ariel Univ. (Israel)
Naor Bokobza, Ariel Univ. (Israel)
Hadas Bloygrund, Ariel Univ. (Israel)
Yarden Franjy-Tal, Ariel Univ. (Israel)
Konstantin Rozenberg, Ariel Univ. (Israel)
Tovit Rosenzweig, Ariel Univ. (Israel)

Published in SPIE Proceedings Vol. 11360:
Francesco Saverio Pavone; Laurent Cognet; Thomas Kuner, Editor(s)

© SPIE. Terms of Use
Back to Top
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?