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Label-free imaging of collagen as a potential diagnostic marker for detection of gliomas
Author(s): Na Fang; Zanyi Wu; Xingfu Wang; Dezhi Kang; Yuanxiang Lin; Jianxin Chen
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Paper Abstract

The collagen in glioma is changed due to remodeling of the extracellular matrix during the malignant process and plays an important role in the progression of human gliomas. In this paper, multiphoton microscopy (MPM) based on twophoton excited fluorescence (TPEF) and second harmonic generation (SHG) was introduced to image the changes of collagen in normal human brain and gliomas. What’s more, together with the image analysis, the collagen content was quantitatively measured. It was found that in gliomas the collagen content significantly increased compared to normal brain tissue. These results suggest that MPM has the capability to provide collagen signature as a potential diagnostic marker for detection of gliomas.

Paper Details

Date Published: 20 December 2019
PDF: 4 pages
Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 112095L (20 December 2019); doi: 10.1117/12.2551593
Show Author Affiliations
Na Fang, Fujian Normal Univ. (China)
Fujian Medical Univ. (China)
Zanyi Wu, The First Affiliated Hospital of Fujian Medical Univ. (China)
Xingfu Wang, The First Affiliated Hospital of Fujian Medical Univ. (China)
Dezhi Kang, The First Affiliated Hospital of Fujian Medical Univ. (China)
Yuanxiang Lin, The First Affiliated Hospital of Fujian Medical Univ. (China)
Jianxin Chen, Fujian Normal Univ. (China)


Published in SPIE Proceedings Vol. 11209:
Eleventh International Conference on Information Optics and Photonics (CIOP 2019)
Hannan Wang, Editor(s)

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