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Proceedings Paper

Rapid fiber-optic Raman spectroscopy: immediate medical diagnosis in gastrointestinal tracts (Conference Presentation)
Author(s): Zhiwei Huang

Paper Abstract

Gastrointestinal (GI) cancer is the second most commonly diagnosed cancer. Early cancer identification is critical to reducing mortality rates of GI patients. Conventional white-light endoscope, however, suffers from poor diagnostic accuracy of GI cancer during endoscopic examination. Raman spectroscopy represents a unique optical vibrational technique capable of harvesting biomolecular information in tissue with potential for tissue histopathological assessments. In this work, we report the development of a novel simultaneous fingerprint (FP) and high wavenumber (HW) fiber-optic Raman spectroscopy technique as well as its clinical applications for improving real-time in vivo diagnosis of GI cancer at endoscopy. We have demonstrated the diagnostic accuracy of >90% for GI cancer and precancer detection with FP/HW Raman spectroscopy. The rapid fiber-optic Raman spectroscopy also allows the

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11252, Advanced Chemical Microscopy for Life Science and Translational Medicine, 112521F (10 March 2020);
Show Author Affiliations
Zhiwei Huang, National Univ. of Singapore (Singapore)

Published in SPIE Proceedings Vol. 11252:
Advanced Chemical Microscopy for Life Science and Translational Medicine
Ji-Xin Cheng; Wei Min; Garth J. Simpson, Editor(s)

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