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Salted cadaver brain measurement for light attenuation of PDT
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Paper Abstract

We investigated light attenuation in a salted cadaver brain at 664 nm, which is the excitation wavelength of photodynamic therapy using Talaporfin sodium. Technology for diagnosis or treatment using light such as photodiagnosis and photodynamic therapy has been spread recently. Especially the therapeutic lesion by photodynamic therapy is dominated by the light distribution in the tissue under the case of uniform photosensitizer distribution. Estimation of therapeutic lesions is important to ensure the effectiveness and safety of brain tumor photodynamic therapy since important parts that should not be damaged are adjacent. Previously reported optical properties of the human brain in the literature vary widely, since the preparation and measurement methods are different. In this study, we measured the light attenuation in a salted cadaver brain using a practical method. In the employed salted cadaver brain, the mechanical and optical properties could be maintained as close as possible to those under operative conditions in living patients. Until the cerebral ventricle was reached, a neuroendoscope was inserted into the brain. A thin diffuse irradiation probe of 10 mm in irradiation length was inserted using the endoscope and advanced 10 mm from the endoscope tip. An optical fiber for measurement was inserted by another path from the brain surface. Optical fiber was put into a puncture needle, and a pair of needles was used to puncture the tissue and reach the same cerebral ventricle in which the endoscope tip and diffuse irradiation probe were positioned. Attenuation at 664 nm in salted cadaver brain in situ was reasonably measured by the withdrawal technique and we think this method might be appropriate for the measurement of inhomogeneous biological tissues.

Paper Details

Date Published: 20 February 2020
PDF: 4 pages
Proc. SPIE 11238, Optical Interactions with Tissue and Cells XXXI, 112381I (20 February 2020);
Show Author Affiliations
Emiyu Ogawa, Kitasato Univ. (Japan)
Jiro Akimoto, Tokyo Medical Univ. (Japan)
Shinjiro Fukami, Tokyo Medical Univ. (Japan)
Tsunenori Arai, Keio Univ. (Japan)
Hiroshi Kumagai, Kitasato Univ. (Japan)

Published in SPIE Proceedings Vol. 11238:
Optical Interactions with Tissue and Cells XXXI
Bennett L. Ibey; Norbert Linz, Editor(s)

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