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Proceedings Paper

Comparing cervical maturation in preterm and term birth mouse models with Raman spectroscopy (Conference Presentation)
Author(s): Rekha Gautam; Jennifer Herington; Naoko Brown; Wilson Adam; Jackson H. Rogers; Jen Bateman; Christine O'Brien; Jeff Reese; Anita Mahadevan-Jansen

Paper Abstract

Preterm birth (PTB), when defined as labor before 37 weeks of gestation, affects approximately 1 out of every 10 births in the United States, leading to high rates of mortality. Complete understanding of the mechanism of PTB requires non-invasive, multi-modal techniques that can provide information about the cascade of labor onset. This study compares the cervical remodeling in wild-type term and induced preterm mouse models using Raman spectroscopy. This study demonstrates the potential of Raman spectroscopy as a non-invasive, real-time in-vivo modality to understand cervix remodeling, thus guiding future studies to improve reproductive and neonatal outcomes.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 112360W (9 March 2020); doi: 10.1117/12.2551333
Show Author Affiliations
Rekha Gautam, Vanderbilt Univ. (United States)
Jennifer Herington, Vanderbilt Univ. Medical Ctr. (United States)
Naoko Brown, Vanderbilt Univ. Medical Ctr. (United States)
Wilson Adam, Vanderbilt Univ. (United States)
Jackson H. Rogers, Vanderbilt Univ. Medical Ctr. (United States)
Jen Bateman, Vanderbilt Univ. (United States)
Christine O'Brien, Vanderbilt Univ. (United States)
Washington Univ. School of Medicine (United States)
Jeff Reese, Vanderbilt Univ. Medical Ctr. (United States)
Anita Mahadevan-Jansen, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 11236:
Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry
Wolfgang Petrich; Zhiwei Huang, Editor(s)

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