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Proceedings Paper

Functional metasurfaces for rapid, colorimetric cancer tissue diagnostics (Conference Presentation)
Author(s): Lisa V. Poulikakos; Mark Lawrence; David R. Barton III; Jennifer A. Dionne

Paper Abstract

We present an all-optical, label-free technology for quantitative, real-time cancer tissue diagnostics on a single, clinically-compatible chip. Periodically-arranged sub-wavelength dielectric nanostructures, known as metasurfaces, are patterned into dielectric layers on glass microscope coverslips, where biopsied tumor tissue sections can be deposited following routine clinical procedure. We numerically and experimentally map the anisotropy and orientation of collagen fibers, a quantitative marker of cancer stage in tissue, onto metasurface structural color. Working at the interface of nanoscale optics and medicine, our colorimetric metasurface platform has the potential to set a new benchmark for rapid, quantitative and cost-effective cancer tissue diagnostics.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 112570I (10 March 2020); doi: 10.1117/12.2551314
Show Author Affiliations
Lisa V. Poulikakos, Stanford Univ. (United States)
Mark Lawrence, Stanford Univ. (United States)
David R. Barton III, Stanford Univ. (United States)
Jennifer A. Dionne, Stanford Univ. (United States)

Published in SPIE Proceedings Vol. 11257:
Plasmonics in Biology and Medicine XVII
Tuan Vo-Dinh; Ho-Pui A. Ho; Krishanu Ray, Editor(s)

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