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Proceedings Paper

Minimally invasive intraperitoneal photodynamic therapy using a new soft robot system
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Paper Abstract

Currently, photodynamic therapy (PDT) of primary tumors in peritoneal organs is limited by the lack of specificity of photosensitizers (PSs) and availability of appropriate laparoscopy for accurate and dexterous PDT optical fiber deployment. Invasive procedures are often required in the conventional approach, leads to significant side effects such as bleeding and extended recovery time. The purpose of this study is to design and evaluate a soft robot system for targeted and minimally invasive PDT of intraperitoneal tumors. Our soft robot system is fabricated with silicone materials to enable safe interaction with the abdominal organs. Compared to the conventional laparoscopic device, this soft robot system can be translated, bent, and rotated to reach the desired target by using three high-resolution DC motors. A miniature camera (ENA-10005-AS, Enable Inc.) is integrated with the soft robot to enable the intraoperative image guidance while reaching the target. A hollow channel was created within the soft robot so as to deploy the optical fiber towards the tumor. We conducted interstitial PDT using a peritoneal ovarian tumor mouse model and targeted near infrared photosensitizer. After the PS was injected, the optical fiber was inserted into the tumors through the soft robot. We found that PDT treatment greatly inhibited tumor growth. Our preliminary results suggest that our soft robot system may have great potential in the PDT treatment of intraperitoneal tumors.

Paper Details

Date Published: 28 February 2020
PDF: 6 pages
Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200D (28 February 2020);
Show Author Affiliations
Yang Liu, Vanderbilt Univ. Medical Ctr. (United States)
Kashu Yamazaki, Univ. of Arkansas (United States)
Dawei Zhang, Vanderbilt Univ. Medical Ctr. (United States)
Yucheng Li, Univ. of Arkansas (United States)
Meng Su, Vanderbilt Univ. Medical Ctr. (United States)
Qing Xie, Vanderbilt Univ. Medical Ctr. (United States)
Yue Chen, Univ. of Arkansas (United States)
Mingfeng Bai, Vanderbilt Univ. Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

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