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Proceedings Paper

Optimization of a plasmonic fluorescence biosensor platform to detect serum antibodies with high sensitivity and consistency (Conference Presentation)
Author(s): Eunice Chou; Arturo Pilar; Ernest Guignon; William Page; George Gibson; Yi-Pin Lin; Nathaniel C. Cady

Paper Abstract

Detection of antibodies in the blood is an important clinical technique for diagnosing active infections and previous exposures. The grating-coupled fluorescent plasmonics (GC-FP) biosensing platform has been used to detect Lyme disease serum antibodies in patients and has been shown to be more sensitive than the current standard tests. In this study, we sought to design an affordable GC-FP detection system without sacrificing the sensitivity of data output. We further optimized our analysis strategies to achieve highly sensitive and consistent diagnostic results. This work ultimately aims to fill an unmet need for better detection of human Lyme disease.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 1125806 (10 March 2020);
Show Author Affiliations
Eunice Chou, SUNY Polytechnic Institute (United States)
Arturo Pilar, Ciencia, Inc. (United States)
Ernest Guignon, Ciencia, Inc. (United States)
William Page, Ciencia, Inc. (United States)
George Gibson, Univ. of Connecticut (United States)
Yi-Pin Lin, Wadsworth Ctr. (United States)
Nathaniel C. Cady, SUNY Polytechnic Institute (United States)

Published in SPIE Proceedings Vol. 11258:
Frontiers in Biological Detection: From Nanosensors to Systems XII
Amos Danielli; Benjamin L. Miller; Sharon M. Weiss, Editor(s)

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