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Proceedings Paper

Toward whole-brain in vivo optoacoustic angiography of rodents (Conference Presentation)

Paper Abstract

We report on a comprehensive theoretical analysis of the optimal wavelengths for in vivo optoacoustic angiography in whole rodent brains. Governed by the competing processes of light attenuation through the brain tissues and optoacoustic signal generation due to absorption by blood, we identified three distinct spectral ranges centered around 580, 895 and 1100 nm optimally suited for imaging of vessels of different size and depth. The developed model was employed for numerical simulation of optoacoustic imaging of murine brain illustrating the effect of probing wavelength on visibility of the cerebral vasculature. In vivo imaging experiments further affirmed the capacity for whole-brain optoacoustic angiography in rodents at a wavelength of 1064nm.

Paper Details

Date Published: 20 April 2020
Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112400O (20 April 2020); doi: 10.1117/12.2551060
Show Author Affiliations
Pavel Vladimirovich Subochev, Institute of Applied Physics (Russian Federation)
Ilya V. Turchin, Institute of Applied Physics of the RAS (Russian Federation)

Published in SPIE Proceedings Vol. 11240:
Photons Plus Ultrasound: Imaging and Sensing 2020
Alexander A. Oraevsky; Lihong V. Wang, Editor(s)

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