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Proceedings Paper

In vivo macro- and micro-Raman spectroscopy for clinical diagnosis and research applications (Conference Presentation)
Author(s): Haishan Zeng

Paper Abstract

Raman spectroscopy is a powerful technique for biochemical composition analysis. The inherent weak signal makes it a great challenge for in vivo tissue analysis. We have developed a platform technology that meets the challenge. One of our systems measures Raman spectra from a macro-size (mm3) tissue volume using a proprietary technology to correct spectrograph image distortion, realized >16 S/N improvement. The macro-Raman system is capable of acquiring a spectrum from tissue in vivo in 1 s, facilitating practical clinical applications. Two application examples will be presented: non-invasive skin cancer detection and endoscopic lung cancer detection. The other system measures Raman from micro-size (um3) tissue volume. It provides confocal imaging monitoring in the whole micro-Raman acquisition period (20 s) to guarantee the measurement stayed on target. Application for non-invasive glucose measurement and for mechanism study of multiphoton phototermolysis therapy will be presented.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 1123606 (9 March 2020);
Show Author Affiliations
Haishan Zeng, BC Cancer Research Ctr. (Canada)
The Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 11236:
Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry
Wolfgang Petrich; Zhiwei Huang, Editor(s)

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