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Proceedings Paper

Precise closure of single blood vessels via multiphoton photothermolysis (Conference Presentation)
Author(s): Yimei Huang; Zhenguo Wu; Harvey Lui; Jianhua Zhao; Shusen Xie; Haishan Zeng

Paper Abstract

We report a novel approach to selectively close single blood vessels within tissue using multiphoton absorption-based photothermolysis. The treatment process is monitored by in vivo reflectance confocal microscopy in real-time. Closure of single targeted vessels of varying sizes ranging from capillaries to venules was demonstrated. We also demonstrated that deeply situated vessels could be closed precisely while preserving adjacent overlying superficial vessels. Partial vessel occlusion could also be achieved, and it is accompanied by intravascular blood cell speed increasing. This approach provides a novel precision medicine method for non-invasive precise microsurgery treatment of vascular diseases on per vessel/per lesion basis.

Paper Details

Date Published: 6 March 2020
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Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110J (6 March 2020);
Show Author Affiliations
Yimei Huang, BC Cancer Research Ctr. (Canada)
Fujian Normal Univ. (China)
Zhenguo Wu, The Univ. of British Columbia (Canada)
BC Cancer Research Ctr. (Canada)
Harvey Lui, The Univ. of British Columbia (Canada)
BC Cancer Research Ctr. (Canada)
Jianhua Zhao, The Univ. of British Columbia (Canada)
BC Cancer Research Ctr. (Canada)
Shusen Xie, Fujian Normal Univ. (China)
Haishan Zeng, BC Cancer Research Ctr. (Canada)
The Univ. of British Columbia (Canada)


Published in SPIE Proceedings Vol. 11211:
Photonics in Dermatology and Plastic Surgery 2020
Bernard Choi; Haishan Zeng, Editor(s)

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