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Proceedings Paper

Weakly supervised 3D classification of chest CT using aggregated multi-resolution deep segmentation features
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Paper Abstract

Weakly supervised disease classification of CT imaging suffers from poor localization owing to case-level annotations, where even a positive scan can hold hundreds to thousands of negative slices along multiple planes. Furthermore, although deep learning segmentation and classification models extract distinctly unique combinations of anatomical features from the same target class(es), they are typically seen as two independent processes in a computer-aided diagnosis (CAD) pipeline, with little to no feature reuse. In this research, we propose a medical classifier that leverages the semantic structural concepts learned via multi-resolution segmentation feature maps, to guide weakly supervised 3D classification of chest CT volumes. Additionally, a comparative analysis is drawn across two different types of feature aggregation to explore the vast possibilities surrounding feature fusion. Using a dataset of 1593 scans labeled on a case-level basis via rule-based model, we train a dual-stage convolutional neural network (CNN) to perform organ segmentation and binary classification of four representative diseases (emphysema, pneumonia/atelectasis, mass and nodules) in lungs. The baseline model, with separate stages for segmentation and classification, results in AUC of 0.791. Using identical hyperparameters, the connected architecture using static and dynamic feature aggregation improves performance to AUC of 0.832 and 0.851, respectively. This study advances the field in two key ways. First, case-level report data is used to weakly supervise a 3D CT classifier of multiple, simultaneous diseases for an organ. Second, segmentation and classification models are connected with two different feature aggregation strategies to enhance the classification performance.

Paper Details

Date Published: 16 March 2020
PDF: 6 pages
Proc. SPIE 11314, Medical Imaging 2020: Computer-Aided Diagnosis, 1131408 (16 March 2020); doi: 10.1117/12.2550857
Show Author Affiliations
Anindo Saha, Univ. de Girona (Spain)
Fakrul I. Tushar, Duke Univ. Medical Ctr. (United States)
Khrystyna Faryna, Univ. de Girona (Spain)
Vincent M. D'Anniballe, Duke Univ. Medical Ctr. (United States)
Rui Hou, Duke Univ. Medical Ctr. (United States)
Maciej A. Mazurowski, Duke Univ. Medical Ctr. (United States)
Geoffrey D. Rubin M.D., Duke Univ. Medical Ctr. (United States)
Joseph Y. Lo, Duke Univ. Medical Ctr. (United States)

Published in SPIE Proceedings Vol. 11314:
Medical Imaging 2020: Computer-Aided Diagnosis
Horst K. Hahn; Maciej A. Mazurowski, Editor(s)

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