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Proceedings Paper

An assessment of PET dose reduction with penalized likelihood image reconstruction using a computationally efficient model observer
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Paper Abstract

Developing PET reconstruction algorithms with improved low-count capabilities may provide a timely and cost- effective means of reducing radiation dose in promising clinical applications such as immuno-PET that require long-lived radiotracers. For many PET clinics, the reconstruction protocol consists of postsmoothed ordered-sets expectation-maximization (OSEM) reconstruction, but penalized likelihood methods based on total-variation (TV) regularization could substantially reduce dose. We performed a task-based comparison of postsmoothed OSEM and higher-order TV (HOTV) reconstructions using simulated images of a contrast-detail phantom. An anthropomorphic visual-search model observer read the images in a location-known receiver operating characteristic (ROC) format. Acquisition counts, target uptake, and target size were study variables, and the OSEM postfiltering was task-optimized based on count level. A psychometric analysis of observer performance for the selected task found that the HOTV algorithm allowed a two-fold reduction in dose compared to the optimized OSEM algorithm.

Paper Details

Date Published: 16 March 2020
PDF: 7 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113120T (16 March 2020); doi: 10.1117/12.2550856
Show Author Affiliations
Howard C. Gifford, Univ. of Houston (United States)
C. Ross Schmidtlein, Memorial Sloan Kettering Cancer Ctr. (United States)
Andrzej Krol, SUNY Upstate Medical Univ. (United States)
Yuesheng Xu, Old Dominion Univ. (United States)


Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

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