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The study of paraffin-embedded tissue using multiphoton microscopy
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Paper Abstract

The of multiphoton microscopy (MPM) based on two-photon fluorescence and second-harmonic generation is promising for diagnosing neoplastic transformation of tissues. The results of MPM studies of tissues with prostate adenocarcinoma embedded in paraffin blocks are presented. The tissue fluorescence was also analyzed using the fluorescence lifetime (Fluorescence-lifetime imaging microscopy - FLIM) option. The relationships between the fluorescence peculiarities and the second harmonic generation of the prostate gland tissues were obtained for different morphological images.

Paper Details

Date Published: 11 December 2019
PDF: 5 pages
Proc. SPIE 11322, XIV International Conference on Pulsed Lasers and Laser Applications, 113222J (11 December 2019); doi: 10.1117/12.2550754
Show Author Affiliations
Anastasia I. Knyazkova, National Research Tomsk State Univ. (Russian Federation)
Institute of Strength Physics and Materials Science (Russian Federation)
Lyudmila V. Spirina, Siberian State Medical Univ. (Russian Federation)
Tomsk National Research Medical Ctr. (Russian Federation)
Viсtor V. Nikolaev, National Research Tomsk State Univ. (Russian Federation)
Institute of Strength Physics and Materials Science (Russian Federation)
Alexey V. Borisov, National Research Tomsk State Univ. (Russian Federation)
Siberian State Medical Univ. (Russian Federation)
Аlexey A. Markelov, Institute of Strength Physics and Materials Science (Russian Federation)
Maxim B. Mirochnichenko, Institute of Strength Physics and Materials Science (Russian Federation)
Elena S. Sim, National Research Tomsk State Univ. (Russian Federation)
Yury V. Kistenev, National Research Tomsk State Univ. (Russian Federation)
Siberian State Medical Univ. (Russian Federation)
Polina A. Timoshina, National Research Tomsk State Univ. (Russian Federation)
Saratov State Univ. (Russian Federation)
Daria K. Tuchina, National Research Tomsk State Univ. (Russian Federation)
Saratov State Univ. (Russian Federation)


Published in SPIE Proceedings Vol. 11322:
XIV International Conference on Pulsed Lasers and Laser Applications
Victor F. Tarasenko; Anton V. Klimkin; Maxim V. Trigub, Editor(s)

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