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Proceedings Paper

The optical property and morphometry of human cerebellum cortex with automatic serial sectioning polarization sensitive optical coherence tomography (Conference Presentation)
Author(s): Hui Wang; Viviana Siless; Morgan Fogarty; Iman Aganj; Douglas Greve; Bruce Fischl

Paper Abstract

Automatic serial sectioning polarization sensitive optical coherence tomography (as-PSOCT) enables volumetric reconstruction of human brain samples with unprecedented resolution and volume coverage. Here we show the laminar structures and the optical properties in human cerebellar cortex using as-PSOCT. The cerebellum cortex was segmented based on the retardance images. The scattering coefficient maps were created, and the thickness maps were generated for the molecular and granular layers, respectively. The relationship between the optical property and the geometry was investigated. The optical property indicated a homogenous cell density despite great variations in the thickness due to the folding patterns in the cerebellum.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260R (9 March 2020); doi: 10.1117/12.2550620
Show Author Affiliations
Hui Wang, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Viviana Siless, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Morgan Fogarty, Washington Univ. in St. Louis (United States)
Iman Aganj, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Douglas Greve, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)
Bruce Fischl, Athinoula A. Martinos Ctr. for Biomedical Imaging, Massachusetts General Hospital (United States)


Published in SPIE Proceedings Vol. 11226:
Neural Imaging and Sensing 2020
Qingming Luo; Jun Ding; Ling Fu, Editor(s)

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