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Proceedings Paper

Using fluorescence laminar optical tomography to measure the distribution photodynamic drug in the brain to optimize dosage and treatment time (Conference Presentation)

Paper Abstract

Glioblastoma has a high rate of recurrence due to treatment methods often failing to penetrate the blood brain barrier. To overcome this limitation, photodynamic priming (PDP) can be used to increase tissue permeability. In this study we investigate the feasibility of using fluorescence laminar optical tomography (FLOT) to provide quantitative distribution information on photodynamic drug in the brain to optimize the timing of PDP. The project will result in a non-invasive way to quantify the concentration of photodynamic drug in the brain. This would allow for optimized treatment times, leading to improved patient outcomes.

Paper Details

Date Published: 20 April 2020
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Proc. SPIE 11219, Visualizing and Quantifying Drug Distribution in Tissue IV, 112190J (20 April 2020); doi: 10.1117/12.2550498
Show Author Affiliations
Brandon Gaitan, Univ. of Maryland, College Park (United States)
Collin T. Inglut, Univ. of Maryland, College Park (United States)
Yu Chen, Univ. of Maryland, College Park (United States)
Huang-Chiao Huang, Univ. of Maryland, College Park (United States)


Published in SPIE Proceedings Vol. 11219:
Visualizing and Quantifying Drug Distribution in Tissue IV
Kin Foong Chan; Conor L. Evans, Editor(s)

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