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Proceedings Paper

Mapping the phonon dispersion in biological matter using angle-resolved Brillouin light scattering microspectroscopy
Author(s): Kareem Elsayad
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Paper Abstract

Biological matter is usually structurally anisotropic. As such the speed of acoustic phonons, which can be probed using Brillouin spectroscopy, depends on the angular-direction. Using a novel spectrometer-setup, which simultaneously probes the acoustic-velocity from different azimuthal angles, we quantify this anisotropy in different biological structures. By point-scanning the sample we render spatial-maps of parts of the phonon dispersion relation and find different regions in live cells have distinct anisotropic properties in their phonon velocity, with variations related to cell-health and phase. I will discuss the physical/biological interpretation of our results, their relevance for understanding/modelling cellular mechanics, and potential diagnostic applications.

Paper Details

Date Published: 13 February 2020
PDF: 12 pages
Proc. SPIE 11242, Optical Elastography and Tissue Biomechanics VII, 112420F (13 February 2020); doi: 10.1117/12.2550449
Show Author Affiliations
Kareem Elsayad, Vienna Biocenter Core Facilities GmbH (Austria)


Published in SPIE Proceedings Vol. 11242:
Optical Elastography and Tissue Biomechanics VII
Kirill V. Larin; Giuliano Scarcelli, Editor(s)

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