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Proceedings Paper

Genetically-produced and bioinspired magnetic nanoparticles as novel photoacoustic contrast agents (Conference Presentation)
Author(s): Julia Watts; Mikyung Han; Mustafa Sarimollaoglu; Zeid A. Nima; Fumiya Watanabe; Azemat Jamshidi-Parsian; Alexandru Biris; Vladimir Zharov; Ekaterina Galanzha

Paper Abstract

Here, we demonstrated that natural magnetic nanoparticles (nMNP) from magnetotactic bacteria can serve as photoacoustic high-contrast agents for single cell analysis. The main benefits of nMNP include biocompatibility and relatively low laser fluence for photoacoustic detection. These features together with safety of photoacoustics provide potential for clinical translation. Further decoration of nMNP with NIR-absorbing gold nanorods provided hybrid nanoparticles with strong NIR absorption and plasmonic effects for cancer cell theranostics. In studies in vivo, we showed that circulating tumor cells labeled with bioinspired hybrids generated transient ultrasharp photoacoustic resonances as the basis for new super-resolution photoacoustic flow cytometry in vivo.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 1123904 (9 March 2020); doi: 10.1117/12.2550396
Show Author Affiliations
Julia Watts, Univ. of Arkansas for Medical Sciences (United States)
Mikyung Han, Univ. of Arkansas for Medical Sciences (United States)
Mustafa Sarimollaoglu, Univ. of Arkansas for Medical Sciences (United States)
Zeid A. Nima, Univ. of Arkansas at Little Rock (United States)
Fumiya Watanabe, Univ. of Arkansas at Little Rock (United States)
Azemat Jamshidi-Parsian, Univ. of Arkansas for Medical Sciences (United States)
Alexandru Biris, Univ. of Arkansas at Little Rock (United States)
Vladimir Zharov, Univ. of Arkansas for Medical Sciences (United States)
Ekaterina Galanzha, Univ. of Arkansas for Medical Sciences (United States)


Published in SPIE Proceedings Vol. 11239:
Dynamics and Fluctuations in Biomedical Photonics XVII
Valery V. Tuchin; Martin J. Leahy; Ruikang K. Wang, Editor(s)

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