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Proceedings Paper

Integrated lymph and blood photoacoustic test for advanced diagnosis of early circulating tumor cells (Conference Presentation)

Paper Abstract

Most fatalities from cancer are caused by metastases produced by circulating tumor cells (CTCs). Despite its importance, CTC diagnosis at an early treatable stage of disease is challenging. Early CTCs can escape from routine blood tests because they are rare events and can migrate between lymph and blood systems. To solve this problem, we introduced photoacoustic flow cytometry in vivo. This clinically-relevant technology is capable of noninvasively counting blood and lymphatic CTCs over disease progression with >1000-times higher sensitivity than existing methods. Here we summarize our preclinical results demonstrating advances of combined lymph+blood diagnosis of CTCs using metastatic melanoma model.

Paper Details

Date Published: 6 March 2020
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Proc. SPIE 11241, Biophotonics and Immune Responses XV, 112410B (6 March 2020); doi: 10.1117/12.2550388
Show Author Affiliations
Mikyung Han, Univ. of Arkansas for Medical Sciences (United States)
Julia Watts, Univ. of Arkansas for Medical Sciences (United States)
Azemat Jamshidi-Parsian, Univ. of Arkansas for Medical Sciences (United States)
Urooba Nadeem, The Univ. of Chicago Medicine (United States)
Mustafa Sarimollaoglu, Univ. of Arkansas for Medical Sciences (United States)
Eric R. Siegel, Univ. of Arkansas for Medical Sciences (United States)
Vladimir P. Zharov, Univ. of Arkansas for Medical Sciences (United States)
Ekaterina I. Galanzha, Univ. of Arkansas for Medical Sciences (United States)


Published in SPIE Proceedings Vol. 11241:
Biophotonics and Immune Responses XV
Wei R. Chen, Editor(s)

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