Share Email Print
cover

Proceedings Paper

Label-free ultrasensitive detection of Amyloid-β using microtoroid resonators with lipid surface functionalization (Conference Presentation)

Paper Abstract

Accurate measurement of Amyloid-β biomarkers in blood serum has been highly sought after for early detection of Alzheimer’s Disease (AD). However, non-specific binding and low levels of Amyloid-β in blood pose a problem for traditional immunoassays. Here, we propose a lipid-functionalized biosensor for real-time, label-free detection of Amyloid-β by interaction with whispering gallery modes (WGM) of a microtoroid optical resonator. Non-specific binding is reduced by uniform surface coverage of the lipid, and protein-lipid interactions enhance the shift in resonance frequency. The lipid surface functionalization scheme enables increased accuracy and sensitivity of Amyloid-β and potential for blood-based screening of AD.

Paper Details

Date Published: 10 March 2020
PDF
Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 112580A (10 March 2020); doi: 10.1117/12.2550381
Show Author Affiliations
Adley Gin, The Univ. of Arizona (United States)
Phuong-Diem Nguyen, The Univ. of Arizona (United States)
Judith Su, The Univ. of Arizona (United States)


Published in SPIE Proceedings Vol. 11258:
Frontiers in Biological Detection: From Nanosensors to Systems XII
Amos Danielli; Benjamin L. Miller; Sharon M. Weiss, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray