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Proceedings Paper

Label-free ultrasensitive detection of Amyloid-β using microtoroid resonators with lipid surface functionalization (Conference Presentation)

Paper Abstract

Accurate measurement of Amyloid-β biomarkers in blood serum has been highly sought after for early detection of Alzheimer’s Disease (AD). However, non-specific binding and low levels of Amyloid-β in blood pose a problem for traditional immunoassays. Here, we propose a lipid-functionalized biosensor for real-time, label-free detection of Amyloid-β by interaction with whispering gallery modes (WGM) of a microtoroid optical resonator. Non-specific binding is reduced by uniform surface coverage of the lipid, and protein-lipid interactions enhance the shift in resonance frequency. The lipid surface functionalization scheme enables increased accuracy and sensitivity of Amyloid-β and potential for blood-based screening of AD.

Paper Details

Date Published: 10 March 2020
Proc. SPIE 11258, Frontiers in Biological Detection: From Nanosensors to Systems XII, 112580A (10 March 2020); doi: 10.1117/12.2550381
Show Author Affiliations
Adley Gin, The Univ. of Arizona (United States)
Phuong-Diem Nguyen, The Univ. of Arizona (United States)
Judith Su, The Univ. of Arizona (United States)

Published in SPIE Proceedings Vol. 11258:
Frontiers in Biological Detection: From Nanosensors to Systems XII
Amos Danielli; Benjamin L. Miller; Sharon M. Weiss, Editor(s)

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