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Proceedings Paper

Measuring dysfunction of cone photoreceptors in retinitis pigmentosa with phase-sensitive AO-OCT
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Paper Abstract

Retinitis Pigmentosa (RP), the most common group of inherited retinal degenerative diseases, is characterized by progressive loss of peripheral vision that surrounds an island of healthy central vision and a transition zone of reduced vision. The most debilitating phase of the disease is cone photoreceptor death whose biological mechanisms remain unknown. Traditional clinical methods such as perimetry and electroretinography are gold standards for diagnosing and monitoring RP and indirectly assessing cone function. Both methods, however, lack the spatial resolution and sensitivity to assess disease progression at the level of individual photoreceptor cells, where it begins. To address this need, we developed an imaging method based on phase-sensitive adaptive optics optical coherence tomography (PS-AO-OCT) that characterizes cone dysfunction in RP subjects by stimulating cone cells with flashes of light and measuring their resulting nanometer-scale changes in optical path length. We introduce new biomarkers to quantify cone dysfunction. We find cone function decreases with increasing RP severity and even in the healthy central area where cone structure appears normal, cones respond differently than cones in the healthy controls.

Paper Details

Date Published: 19 February 2020
PDF: 8 pages
Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121815 (19 February 2020); doi: 10.1117/12.2550216
Show Author Affiliations
Ayoub Lassoued, Indiana Univ. (United States)
Furu Zhang, Indiana Univ. (United States)
Kazuhiro Kurokawa, Indiana Univ. (United States)
Yan Liu, Indiana Univ. (United States)
James A. Crowell, Indiana Univ. (United States)
Donald T. Miller, Indiana Univ. (United States)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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