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Proceedings Paper

Effect of a mild, diffuse central retinal edema on light evoked outer retina optophysiology signals measured in vivo in mice with optical coherence tomography (Conference Presentation)
Author(s): Robert J. Zawadzki; Pengfei Zhang; Ratheesh K. Meleppat; Edward N. Pugh Jr.

Paper Abstract

Over last few years Optical Coherence Tomography has allowed precise observations of the light-evoked opthophysiological response of the inner and outer retina. In mouse rods this manifests itself as outer segments elongation that is driven by phototransduction. Given the current model describing these observations as osmotically driven water movements we have decided to alter retinal water homeostasis to see if, and how the measured signals will be affected. Our observations of light-evoked retina responses during mild, diffuse central retinal edema confirmed that water plays a key role in this process.

Paper Details

Date Published: 9 March 2020
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Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181A (9 March 2020); doi: 10.1117/12.2550205
Show Author Affiliations
Robert J. Zawadzki, Univ. of California, Davis (United States)
Pengfei Zhang, Univ. of California, Davis (United States)
Ratheesh K. Meleppat, Univ. of California, Davis (United States)
Edward N. Pugh Jr., Univ. of California, Davis (United States)


Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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