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Proceedings Paper

OCT and fluorescence SLO for guided laser delivery and longitudinal imaging in a murine model of targeted retinal laser injury (Conference Presentation)

Paper Abstract

Mice are commonly used to model human retinal disease because of similarities in ocular anatomy and function and availability of transgenic phenotypes. Recently, targeted delivery of photo-lesions has been demonstrated using fundus imaging and a combined optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) system; however, these systems precluded simultaneous multimodality imaging. Here, we present multimodality OCT+SLO imaging combined with a photocoagulation laser and custom software that allows for targeted delivery of focal retinal laser injury under real-time en face OCT guidance. Longitudinal imaging results show lesions with varying degrees of retinal damage during an injury titration study.

Paper Details

Date Published: 9 March 2020
Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181E (9 March 2020); doi: 10.1117/12.2550167
Show Author Affiliations
Joseph D. Malone, Vanderbilt Univ. (United States)
Edward M. Levine, Vanderbilt Univ. (United States)
Yuankai K. Tao, Vanderbilt Univ. (United States)

Published in SPIE Proceedings Vol. 11218:
Ophthalmic Technologies XXX
Fabrice Manns; Arthur Ho; Per G. Söderberg, Editor(s)

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