Share Email Print
cover

Proceedings Paper

Is PDT-based metastatic reduction a consequence of local tumor control or a true abscopal effect in immunodeficient mice? (Conference Presentation)
Author(s): Tayyaba Hasan

Paper Abstract

Despite the concept of Photodynamic Therapy (PDT) being over a century old and regulatory approvals being worldwide for limited indications, PDT is not as broadly used for cancer treatment as promising pre-clinical observations might indicate. One of reasons maybe that it is primarily viewed as a local therapy, yet it is used in patients with advanced disease often in the palliative setting and with metastatic disease. The effect of PDT on metastatic disease has not been studied in any detail. We have reported both an increase and a decrease of metastatic burden. Increased survival in tumor bearing mice along with a decrease in metastatic burden has been demonstrated in both immune competent and immune deficient mice. While in immune competent mice this observation has been attributed to the activation of the mouse immune system, the explanation is less clear in immune suppressed mice (patients?).

Paper Details

Date Published: 10 March 2020
PDF
Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122003 (10 March 2020); doi: 10.1117/12.2549954
Show Author Affiliations
Tayyaba Hasan, Massachusetts General Hospital (United States)
Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 11220:
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX
David H. Kessel; Tayyaba Hasan, Editor(s)

© SPIE. Terms of Use
Back to Top
PREMIUM CONTENT
Sign in to read the full article
Create a free SPIE account to get access to
premium articles and original research
Forgot your username?
close_icon_gray