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Long-term neuroanatomical effects of germ cell tumors after cranial radiation therapy
Author(s): Sinchai Tsao; Niharika Gajawelli; Arthur Olch; Kenneth Wong; Nicholas Chapman; Jeffrey Tanedo; Marvin D. Nelson; Mary Baron Nelson; Natasha Lepore
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Paper Abstract

As improved treatments have increased survival rates for pediatric brain tumor patients, there is an urgent need to study the long-term sequelae of treatment. Central nervous system (CNS) germ cell tumors constitute a form of neoplasm that is normally treated with chemotherapy and/or cranial radiation therapy (CRT). Starting from an MRI dataset of patients with such tumors at Children's Hospital Los Angeles, we aim to understand the morphological effects of CRT on brain structures. The current study examines the long-term effects of radiation dosage on the brainstem, corpus callosum, and ventricles post- radiation therapy. The results of the analysis showed a significant association among brain structure areas and radiation dosage received. These preliminary findings point to deleterious effects of radiation treatment on brain anatomy.

Paper Details

Date Published: 3 January 2020
PDF: 7 pages
Proc. SPIE 11330, 15th International Symposium on Medical Information Processing and Analysis, 113300N (3 January 2020); doi: 10.1117/12.2549911
Show Author Affiliations
Sinchai Tsao, Voxel Healthcare (United States)
Niharika Gajawelli, Voxel Healthcare (United States)
Children's Hospital Los Angeles (United States)
Arthur Olch, Children's Hospital Los Angeles (United States)
Keck Medicine of USC (United States)
Kenneth Wong, Children's Hospital Los Angeles (United States)
Keck Medicine of USC (United States)
Nicholas Chapman, Children's Hospital Los Angeles (United States)
Jeffrey Tanedo, Children's Hospital Los Angeles (United States)
Univ. of Southern California (United States)
Marvin D. Nelson, Children's Hospital Los Angeles (United States)
Keck Medicine of USC (United States)
Mary Baron Nelson, Children's Hospital Los Angeles (United States)
Keck Medicine of USC (United States)
Natasha Lepore, Voxel Healthcare (United States)
Children's Hospital Los Angeles (United States)
Univ. of Southern California and Keck Medicine of USC (United States)


Published in SPIE Proceedings Vol. 11330:
15th International Symposium on Medical Information Processing and Analysis
Eduardo Romero; Natasha Lepore; Jorge Brieva, Editor(s)

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