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Proceedings Paper

Three material decomposition for spectral imaging without contrast agents in photon-counting CT–modeling and feasibility study
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Paper Abstract

Implemented with energy-integration x-ray detector, dual energy spectral CT has been playing increasingly important roles in the clinic for diagnostic imaging. Encouraged by the clinical value added by dual energy spectral CT in oncological, cardiovascular and neurovascular applications, the technological community is investing more resource and effort on photon-counting spectral CT that is anticipated to outperform its energy-integration counterpart in many advanced clinical applications. Based on the preliminary data of phantom and animal studies acquired using a prototype photoncounting spectral CT system, we revisit the underlying physics, mathematics, dimensionality of material space and selection of basis materials for spectral imaging. Focused on three-material decomposition for virtual monochromatic imaging/analysis, we investigate the feasibility and performance of spectral imaging without contrast agents in photoncounting CT, along with an in-depth analysis of the pros and cons of three-material decomposition over two-material decomposition for spectral imaging.

Paper Details

Date Published: 16 March 2020
PDF: 9 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113124W (16 March 2020); doi: 10.1117/12.2549660
Show Author Affiliations
Xiangyang Tang, Emory Univ. School of Medicine (United States)
Yan Ren, Emory Univ. School of Medicine (United States)
Huiqiao Xie, Emory Univ. School of Medicine (United States)
Wenting Long, Emory Univ. School of Medicine (United States)


Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

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