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Proceedings Paper

Automatic brain structure-guided registration of pre and intra-operative 3D ultrasound for neurosurgery
Author(s): Soumya Ghose; David Mills; Jhimli Mitra; L. Scott Smith; Desmond Teck-Beng Yeo; Alexandra Golby; Sarah Frisken; Thomas K. Foo
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Paper Abstract

Image guidance aids neurosurgeons in making critical clinical decisions of safe maximal resection of diseased tissue. The brain however undergoes significant non-linear structural deformation on account of dura opening and tumor resection. Deformable registration of pre-operative ultrasound to intra-operative ultrasound may be used in mapping of pre-operative planning MRI to intraoperative ultrasound. Such mapping may aid in determining tumor resection margins during surgery. In this work, brain structures visible in pre- and intra-operative 3D ultrasound were used for automatic deformable registration. A Gaussian mixture model was used to automatically segment structures of interest in pre- and intra-operative ultrasound and patch-based normalized cross-correlation was used to establish correspondences between segmented structures. An affine registration based on correspondences was followed by B-spline based deformable registration to register pre- and intra-operative ultrasound. Manually labelled landmarks in pre- and intra-operative ultrasound were used to quantify the mean target registration error. We achieve a mean target registration error of 1.43±0.8 mm when validated with 17 pre- and intra-operative ultrasound image volumes of a public dataset.

Paper Details

Date Published: 16 March 2020
PDF: 6 pages
Proc. SPIE 11315, Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling, 113150J (16 March 2020); doi: 10.1117/12.2549630
Show Author Affiliations
Soumya Ghose, General Electric Research (United States)
David Mills, General Electric Research (United States)
Jhimli Mitra, General Electric Research (United States)
L. Scott Smith, General Electric Research (United States)
Desmond Teck-Beng Yeo, General Electric Research (United States)
Alexandra Golby, Brigham and Women's Hospital (United States)
Sarah Frisken, Brigham and Women's Hospital (United States)
Thomas K. Foo, General Electric Research (United States)


Published in SPIE Proceedings Vol. 11315:
Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling
Baowei Fei; Cristian A. Linte, Editor(s)

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