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Proceedings Paper

Hybrid energy integrating and photon counting micro-CT
Author(s): M. D. Holbrook; D. P. Clark; C. T. Badea
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Paper Abstract

The maturation of photon-counting detector (PCD) technology promises to enhance routine CT applications with high-fidelity spectral information, transforming X-ray CT into a functional and molecular imaging modality, while maintaining the high spatial resolution, fast scanning times, and relatively low cost. We present our novel dual source pre-clinical micro-CT prototype system that combines a photon counting detector (PCD) and an energy integrating detector (EID) in a single system. We compare performance for PCD-only with combined hybrid (i.e. PCD and EID) CT imaging with equal dose. All CT data sets (EID-only, PCD-only, and hybrid) were reconstructed using our iterative, multi-channel algorithm based on the split Bregman method and regularization with rank-sparse kernel regression. We used a post-reconstruction decomposition method with iodine (I), gold (Au), gadolinium (Gd), and calcium (Ca) basis functions. Performance was assessed using micro-CT phantoms. Our results show the spatial resolution of the PCD-only and the hybrid reconstructions were similar and slightly better than for EID-only reconstruction with ~3.5 lp/mm (10% MTF). The NPS of the hybrid reconstruction was similar to PCD-only reconstruction. By co-reconstructing EID and PCD data, we achieved better image quality in the material decomposition but marginal differences in terms of concentration accuracy. Hybrid spectral micro- CT can benefit both nanotechnology and cancer research by providing imaging that can help test and optimize various NPs for theranostics.

Paper Details

Date Published: 16 March 2020
PDF: 6 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113120F (16 March 2020); doi: 10.1117/12.2549603
Show Author Affiliations
M. D. Holbrook, Duke Univ. (United States)
D. P. Clark, Duke Univ. (United States)
C. T. Badea, Duke Univ. (United States)

Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

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