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Proceedings Paper

Determining the optimal angular range of the x-ray source motion in tomosynthesis using virtual clinical trials
Author(s): Bruno Barufaldi; Trevor L. Vent; Raymond J. Acciavatti; Predrag R. Bakic; Peter B. Noël; Emily F. Conant; Andrew D. A. Maidment
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Paper Abstract

The limited angle and limited number of projections in digital breast tomosynthesis (DBT) produce under-sampled datasets that may compromise calcification detection. Small breast lesions, such as microcalcifications, may not be discernible without sufficient sampling in the reconstructed DBT images. We propose a virtual clinical trial (VCT) method to evaluate the calcification detection in DBT using computer simulations of breast phantoms, images, and virtual readers. We used multiple-reader multiple-case (MRMC) receiver operating characteristic (ROC) analyses to evaluate the performance of channelized Hotelling observers (CHOs) in calcification detection. The angular motion path of the x-ray source was varied to simulate different DBT acquisition geometries. We simulated continuous and step-and-shoot x-ray source motion and three angular motion paths: ±7.5°, ±15°, and ±25°. The detection of calcifications is affected by the angular motion path, particularly for the ±25° angular range, combined with continuous tube motion, larger detector element sizes (0.14 mm) and larger reconstructed voxel sizes (0.10 mm). When an angular range of ±25° is compared to ±7.5°, the difference in the area under the curve (AUC) is -0.030 (d’ ratio=0.633) and -0.067 (d’ ratio=0.584), for one and two- voxel calcifications (0.1 mm³ and 0.2 mm³), respectively. There is no significant difference in calcification detection using images acquired with ±7.5° and ±15°. The results provide insight on the impact of angular range for calcification detection, an ongoing limitation of tomosynthesis.

Paper Details

Date Published: 16 March 2020
PDF: 7 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113120I (16 March 2020); doi: 10.1117/12.2549600
Show Author Affiliations
Bruno Barufaldi, Univ. of Pennsylvania (United States)
Trevor L. Vent, Univ. of Pennsylvania (United States)
Raymond J. Acciavatti, Univ. of Pennsylvania (United States)
Predrag R. Bakic, Univ. of Pennsylvania (United States)
Peter B. Noël, Univ. of Pennsylvania (United States)
Emily F. Conant, Univ. of Pennsylvania (United States)
Andrew D. A. Maidment, Univ. of Pennsylvania (United States)

Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

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