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Proceedings Paper

Molecularly targeted Lipo-JICG for in vivo quantitative photoacoustic imaging (Conference Presentation)
Author(s): Cayla Wood; Chang Soo Kim; Sangheon Han; Yunfei Wen; Caterina Kaffes; Jason Cook; Anil Sood; Konstantin Sokolov; Richard Bouchard

Paper Abstract

Photoacoustic imaging (PAI) is a non-ionizing modality that provides high spatiotemporal resolution and resolves optical absorbers at depth, allowing for potential simultaneous therapy monitoring with quantitative molecular imaging. Liposome-encapsulated J-aggregates of indocyanine green (Lipo-JICG) are a PAI agent that can be antibody-targeted and provide high-contrast imaging. Mice with ovarian tumors were injected with either targeted or untargeted Lipo-JICGs and imaged on the MSOT inVision PAI system before injection and immediately, 30-min, and 1-hour post-injection. Lipo-JICG contrast in the tumor was statistically significantly higher in the targeted mice, indicating success in molecular targeting and unmixing accuracy of Lipo-JICGs in vivo.

Paper Details

Date Published: 17 March 2020
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Proc. SPIE 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography, 1131902 (17 March 2020); doi: 10.1117/12.2549594
Show Author Affiliations
Cayla Wood, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Chang Soo Kim, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Sangheon Han, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Yunfei Wen, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Caterina Kaffes, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Jason Cook, NanoHybrids, Inc. (United States)
Anil Sood, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Konstantin Sokolov, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)
Richard Bouchard, The Univ. of Texas M. D. Anderson Cancer Ctr. (United States)


Published in SPIE Proceedings Vol. 11319:
Medical Imaging 2020: Ultrasonic Imaging and Tomography
Brett C. Byram; Nicole V. Ruiter, Editor(s)

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