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Proceedings Paper

A preclinical large-field-of-view x-ray multi-contrast lung imaging prototype
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Paper Abstract

By integrating three absorption gratings with a medical X-ray tube and a medical flat panel detector, a preclinical X-ray multi-contrast lung imaging prototype with a large field-of-view up to 40 × 50 cm2 was developed in this work. The prototype system provides phase-contrast and dark-field images simultaneously in addition to the conventional X-ray absorption imaging. Unlike the traditional grating-based phase-contrast imaging (GPCI) system, the scanning object is placed behind the pattern-generating grating G1, reducing the radiation dose to probably half of the original system design. For a fast scan process, three absorption gratings inducing a large field-of-view were utilized. Besides, the X-ray tube, the three gratings and the detector are all fixed on the same mechanical arm, scanning the object along the vertical direction. A numerical simulation platform was developed to help optimize the imaging parameters. Finally, the preliminary experimental results of a full-body enthanized rabbit demonstrate the capability of the multi-contrast prototype system, and its dark-field images are capable of providing additional diagnostic value for the diagnosis of lung diseases. Direct evaluation of the potential clinical unity of the multi-contrast lung imaging can be further performed on this prototype system.

Paper Details

Date Published: 16 March 2020
PDF: 8 pages
Proc. SPIE 11312, Medical Imaging 2020: Physics of Medical Imaging, 113121A (16 March 2020); doi: 10.1117/12.2549560
Show Author Affiliations
Xinbin Li, Tsinghua Univ. (China)
Zhiqiang Chen, Tsinghua Univ. (China)
Li Zhang, Tsinghua Univ. (China)
Hewei Gao, Tsinghua Univ. (China)
Chengpeng Wu, Tsinghua Univ. (China)
Xiaohua Zhu, Tsinghua Univ. (China)

Published in SPIE Proceedings Vol. 11312:
Medical Imaging 2020: Physics of Medical Imaging
Guang-Hong Chen; Hilde Bosmans, Editor(s)

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