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Proceedings Paper

Label-free imaging of bile duct tissues with multiphoton microscopy
Author(s): Caihong Sun; Yu Zhang; Xueqin Xu; Guangxing Wang; Hongxin Lin; Youting Chen; Shuangmu Zhuo
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Paper Abstract

The structural characteristics of bile duct tissue can indirectly reflect the physiological function of the bile duct, so understanding the pathological process of bile duct tissue can improve the prognosis of intrahepatic cholangiocarcinoma. However, the existing technology cannot accurately and quickly determine the stage of the bile duct tissue lesion, which will have a certain impact on the treatment. In this study, normal bile ducts, inflammatory bile ducts, and intrahepatic cholangiocarcinoma were distinguished using label-free multiphoton microscopy (MPM). The experimental results show that high-resolution images can clearly distinguish normal bile duct, inflammatory bile duct and intrahepatic cholangiocarcinoma through cell morphology and tissue structure. Therefore, MPM can be used as an effective optical tool for the diagnosis of intrahepatic cholangiocarcinoma in unstained histological sections. It is expected in the future that MPM can play a greater role in the clinic.

Paper Details

Date Published: 20 December 2019
PDF: 5 pages
Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 112094A (20 December 2019); doi: 10.1117/12.2549530
Show Author Affiliations
Caihong Sun, Fujian Normal Univ. (China)
Yu Zhang, Fujian Normal Univ. (China)
Xueqin Xu, Fujian Normal Univ. (China)
Guangxing Wang, Fujian Normal Univ. (China)
Hongxin Lin, Fujian Normal Univ. (China)
Youting Chen, Fujian Medical Univ. (China)
Shuangmu Zhuo, Fujian Normal Univ. (China)

Published in SPIE Proceedings Vol. 11209:
Eleventh International Conference on Information Optics and Photonics (CIOP 2019)
Hannan Wang, Editor(s)

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