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Proceedings Paper

3D microstructure analysis of human pulmonary emphysema using a synchrotron radiation CT
Author(s): Kurumi Saito; Shota Fuketa; Ryouhei Shimatani; Yoshiki Kawata; Noboru Niki; Keiji Umetani; Yasutaka Nakano; Hiroaki Sakai; Toshihiro Okamoto; Harumi Itoh
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Paper Abstract

Progressive life-threatening lung disease is serious illness. Quantitative three-dimensional (3D) analysis of microstructure of human lung provides detailed information to understand the onset and progression of lung disease. We reported how to analyze normal structures of pulmonary lobule. This study is to elucidate 3D microstructures of emphysema. Two specimens of emphysema are examined using SRμCT. Compare 3D microstructures of bronchial and vasculature between emphysema and normal lungs. Eleven lung specimens were inflated and fixed using the Heitzman fixation method. These measurement experiments were performed at 20 or 25 keV X-ray energy on the SPring-8 beamline BL20B2. The reconstructed 3D image is about 13,370 x 13,370 x 4,900 voxels with an isotropic voxel size of 3μm. Vasculature and bronchi were extracted using a hierarchical algorithm with curvature analysis. The capillary bed and alveoli clusters of normal lung and emphysema were analyzed. In the case of emphysema, large alveoli clusters and thinner capillary beds were observed.

Paper Details

Date Published: 28 February 2020
PDF: 6 pages
Proc. SPIE 11317, Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging, 113170H (28 February 2020); doi: 10.1117/12.2549441
Show Author Affiliations
Kurumi Saito, Tokushima Univ. (Japan)
Shota Fuketa, Tokushima Univ. (Japan)
Ryouhei Shimatani, Tokushima Univ. (Japan)
Yoshiki Kawata, Tokushima Univ. (Japan)
Noboru Niki, Tokushima Univ. (Japan)
Keiji Umetani, Japan Synchrotron Radiation Research Institute (Japan)
Yasutaka Nakano, Shiga Univ. of Medical Science (Japan)
Hiroaki Sakai, Hyogo Prefectural Amagasaki General Medical Ctr. (Japan)
Toshihiro Okamoto, Cleveland Clinic Heart and Vascular Institute (United States)
Harumi Itoh, Univ. of Fukui (Japan)

Published in SPIE Proceedings Vol. 11317:
Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging
Andrzej Krol; Barjor S. Gimi, Editor(s)

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